After I started to run the Eddie for Android I noticed that I was not getting any messages or calls in Signal Messenger. I also had problems with some apps on my Android Wear watch like weather that wouldn't update. As soon as I closed the VPN connection I got a stream of Signal messages and notifications and the weather app on my watch worked again. This makes it totally impractical for me to use the Eddie for Android if that setting is enabled. So I decided to disable it and get a serious warning that security was compromised. I have used the OpenVPN Connect app with AirVPN for a while without such problems. Maybe that client doesn't have the Persistent Tunnel settings? Anyway, if it turns out I have to have Persistent Tunnel set I just can't use Eddie for Android since apps and services I use all day just doesn't work.
There should be a warning that the Persistent Tunnel setting may cause apps and services to not work on the phone. I now run without it and feel compromised but do not know whether I'm more compromised than I was using the OpenVPN Connect client or other VPN services on Android.
Could someone who knows more about these things than I do please clarify and explain the thinking behind the setting and the warning when it's being disabled.